Neuroscience Seminar Series

19 Oct 2023 12:00 - 01:00 — MPINB

We are delighted to announce our next Neuroscience Seminar Series talk. Presentations by experts in their field will take place both here at MPINB and via Zoom.

"The significance of self-generated sensory feedback"

Georg Keller, Friedrich Miescher Institute for Biomedical Research


Psychosis impairs the brain's ability to differentiate between external and self-generated activity patterns. Antipsychotic drugs, which affect various neuromodulator receptors, can mitigate psychosis in humans. However, their impact on cortical circuits, particularly in distinguishing between self-generated and external activity patterns, remains unclear. To study this, we used a virtual reality setup to control self-generated sensory feedback. Through widefield calcium imaging in mouse dorsal cortex, we found that antipsychotic drugs, like clozapine, disrupted visuomotor integration primarily in deep cortical layers. This effect was evident in the correlation structure of activity patterns across cortical areas, suggesting that these drugs selectively alter long-range layer 5 mediated communication.


MPINB Lecture Hall, Ludwig-Erhard-Allee 2, 53175 Bonn


Meeting-ID: 637 6730 0567

To the overview

Ludwig-Erhard-Allee 2
53175 Bonn