Press Release

Sperm can do calculus!

1 Mar 2012 at 08:15

The speed at which the calcium concentration in the cell changes controls the swimming behaviour of sperm. They can calculate the calcium dynamics and react accordingly.

Bonn, 01.03.2012.
Sperm have only one aim: to find the egg. The egg supports sperm in their quest by emitting attractants that induce changes in the calcium level inside sperm. Calcium ions determine the beating pattern of the sperm tail which enables sperm to steer. Together with colleagues from the Max Planck Institute for the Physics of Complex Systems in Dresden and the University of Göttingen, scientists from the caesar research center in Bonn, an institute of the Max Planck Society, have discovered that sperm only react to changes in calcium concentration but not to the calcium concentration itself. Probably sperm make this calculation so that they remain capable of manoeuvring even in the presence of high calcium concentration.

The swimming path on which sperm follow the mating call of the egg, varies according to species. Sperm – in particular those of marine species – swim along convoluted paths in a chemical concentration gradient. Their swimming style is controlled by the calcium ions in the sperm tail. It was previously believed that at high calcium concentration, the sperm tails make asymmetrical, whip-like movements and their swimming path is very curved, while at low calcium concentration, the tail beats symmetrically and sperm swim on a straight line. The alternation of high and low calcium concentrations was thought to steer sperm along spiral-shaped swimming paths. However, this simple model was in contradiction with experiments on freely-swimming sperm and presented the investigators with something of a mystery.

The scientists have now succeeded into solving this mystery. Using an ingenious stroboscopic laser illumination – similar to that used in discotheques – the project leader Luis Alvarez was able to trace the movement of sperm in detail, and simultaneously measure the changes in the calcium concentration. The result was astonishing: the sperm tail only reacted to the time derivative of the calcium concentration and the absolute concentration was of little relevance. To put it simply: sperm can perform calculus! Exactly how they do this is unclear. The caesar scientists suspect that sperm detect calcium ions with the help of two proteins. Calcium binds to one protein fast and to the other slow. By comparing the amount of calcium bound on both proteins can compute a “chemical derivative”, so to speak.

But why do sperm carry out this complicated calculation that we first encounter at the upper secondary school level? The concentration of the attractants and, therefore also, the calcium concentration in sperm is very high near the egg. The mathematical trick probably enables sperm to be able to react even in the presence of such high calcium concentration.

Apart from calcium, many other intracellular messenger control cell functions. Is it therefore possible that, cells in general, also perform complex chemical calculations involving other intracellular messengers? The scientists at Bonn would like to address this important question in the future.


The movie displays a sperm cell loaded with a calcium indicator. The brightness of the cell is a measure of the intracellular calcium concentration. The cell is stimulated with an intense flash of light that activates a chemical substance residing inside the cell. This substance is, under natural conditions, produced when the cell detects the chemoattractant released by the egg. During the movie is shown the curvature of the swimming path, the relative calcium concentration (Fr), and the speed of change of the intracellular calcium (time derivative).

Original publication
Alvarez, L., Dai, L., Friedrich, B. M., Kashikar, N., Gregor, I., Pascal, R. & Kaupp, U. B. (2012) "The rate of change in Ca2+ concentration controls sperm chemotaxis" J. Cell. Biol. 196, 653-663

Online publication: 27 February 2012.
doi: 10.1083/jcb.201106096

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