Neuroscience Seminar Series

Wir freuen uns, unseren nächsten Vortrag der Neuroscience Seminar Series anzukündigen. Präsentationen von Experten auf ihrem Gebiet werden sowohl hier am MPINB als auch über Zoom stattfinden. Die Veranstaltung findet in englischer Sprache statt.

"The significance of self-generated sensory feedback"

Georg Keller, Friedrich Miescher Institute for Biomedical Research

Abstract

Psychosis impairs the brain's ability to differentiate between external and self-generated activity patterns. Antipsychotic drugs, which affect various neuromodulator receptors, can mitigate psychosis in humans. However, their impact on cortical circuits, particularly in distinguishing between self-generated and external activity patterns, remains unclear. To study this, we used a virtual reality setup to control self-generated sensory feedback. Through widefield calcium imaging in mouse dorsal cortex, we found that antipsychotic drugs, like clozapine, disrupted visuomotor integration primarily in deep cortical layers. This effect was evident in the correlation structure of activity patterns across cortical areas, suggesting that these drugs selectively alter long-range layer 5 mediated communication.

In-Person

MPINB Lecture Hall, Ludwig-Erhard-Allee 2, 53175 Bonn

Zoom

https://mpinb-mpg-de.zoom.us/j/63767300567
Meeting-ID: 637 6730 0567

To the overview